Memory loss, confusion and disorientation are the three well-known signs of Alzheimer’s disease.
Yet, there are dozens of subtle behavioral changes that can also point to the cruel life-robbing condition.
Before the disease’s most devastating symptoms even begin, sufferers can experience a change in mood and start to wear scruffier clothes.
And scientists this week uncovered another potential sign.
Researchers at the University of Southern California (USC) found elderly people who were more willing to give away money to a stranger appeared to be at a higher risk of being struck down.
Alzheimer’s affects around 850,000 people in the UK and 5.8million in the US, but charities fear rates will soar across the world in the coming decades as populations age.
Here, MailOnline reveals some of the other unusual signs you or a loved one could have Alzheimer’s.
While memory loss, confusion and disorientation are all well-known signs of Alzheimer’s disease, experts have also discovered dozens of subtle behaviors that could point to the condition. Graphic shows: Six signs of Alzheimer’s disease
giving out money
Elderly people are known to be more at risk of scams.
But the latest research also shows handing out money may potentially be an early sign of Alzheimer’s.
Researchers from USC and Bar-Ilan University in Israel found financial altruism was significantly linked with being in the first stages of the disease.
The researchers gathered 67 elderly adults around the age of 70 for the study.
Each participant was paired with another person they had never met before in a lab environment, and handed $10 (£8) to distribute between themselves and the other.
The elderly participants were also given neurological tests to judge their current cognitive state and their potential risk of developing Alzheimer’s.
Researchers found that those who were willing to give more money to a person they had never met before were also often in a worse cognitive state, suggesting they were at a higher risk of Alzheimer’s.
The results, published their findings in the Journal of Alzheimer’s Disease, suggested the disease’s effects on the brain could have a knock-on effect that makes people more vulnerable to handing out cash.
Dr Duke Han, the neuropsychology professor at USC who led the research, said: ‘Trouble handling money is thought to be one of the early signs of Alzheimer’s disease, and this finding supports that notion.’
What is Alzheimer’s?
Alzheimer’s disease is a progressive, degenerative disease of the brain, in which build-up of abnormal proteins causes nerve cells to die.
This disrupts the transmitters that carry messages, and causes the brain to shrink.
More than 5 million people suffer from the disease in the US, where it is the 6th leading cause of death, and more than 1 million Britons have it.
The brain cells die, the functions they provide are lost.
That includes memory, orientation and the ability to think and reason.
The progress of the disease is slow and gradual.
On average, patients live five to seven years after diagnosis, but some may live for ten to 15 years.
- Loss of short-term memory
- Behavioral changes
- mood swings
- Difficulties dealing with money or making a phone call
- Severe memory loss, forgetting close family members, familiar objects or places
- Becoming anxious and frustrated over inability to make sense of the world, leading to aggressive behavior
- Eventually lose ability to walk
- May have problems eating
- The majority will eventually need 24-hour care
Source: Alzheimer’s Association
Changes to humor
Being a big fan of Mr Bean could be another sign of Alzheimer’s, according to research.
University College London (UCL) researchers found people suffering from the disease were more likely to enjoy slapstick over satirical or absurdist comedy shows than healthy adults of the same age.
Friends and relatives of 48 people with Alzheimer’s and frontotemporal dementia (FTD) — an uncommon type of dementia that causes problems with behavior and language — were given questionnaires about their loved one’s liking for different kinds of comedy.
They were asked whether people enjoyed slapstick comedy like the Rowan Atkinson, satirical comedy such as South Park or absurdist comedy like The Might Boosh.
Family members were also asked if their relative had shifted their preference over the last 15 years and if they ever noticed any inappropriate humor more recently.
The study, published in the Journal of Alzheimer’s Disease in 2015, found people with Alzheimer’s started to prefer slapstick jokes around nine years before the start of typical dementia symptoms.
People with FTD were also more likely to laugh at tragic events on the news or in their personal life, or events others would not find funny such as a badly parked car or barking dog.
Researchers said more studies are needed to determine the exact cause of the changes in mood, but most behavioral changes after developing Alzheimer’s are caused by the brain shrinking in the frontal lobe.
People with Alzheimer’s can also struggle with choosing clothes that go well together and wearing things that are weather-appropriate when left unaided.
Researchers at the universities of Kent and York described how people suffering with dementia — which is most commonly caused by Alzheimer’s — became less able to dress themselves.
The research, published in Sociology of Health and Illness in 2018, studied 32 people across three care homes and 15 regular homes in Kent.
It also interviewed 29 family carers and relatives and 28 care home staff to get their opinions on how to dress people suffering with dementia
Melissa, a family carer who was quoted in the study, described her devastation after her father started to change how he was dressing when he got Alzheimer’s.
She said: ‘I’ve never seen my dad scruffy. never. Until that day I turned up in the home and he’s sitting there in screwed up clothes which really hurt me because I’m not used to that – not at all.’
Carers also described difficulties getting people with more advanced dementia into clothes, having to guide their arms and give encouragement.
Changes in dressing can be caused by a variety of Alzheimer’s effects, from forgetting the clothes belong to them to muscle stiffness and sudden jolty movements making it harder to put them on.
Alzheimer’s patient’s driving can also get significantly worse as the condition starts to affect their motor skills and thought processes, studies show.
The disease slows people’s reactions, making them worse at parking and eventually forcing them to give up the keys to their car.
Stopping driving can often cause people with the memory-robbing condition to become stressed and agitated, because of the perceived sacrifice in autonomy.
Researchers from Washington University in St Louis studied driving habits in 139 people over a year to see how the disease impacted them. Half were diagnosed with early Alzheimer’s while the other half were not.
The study, published in Alzheimer’s Research and Therapy in 2021, found those with the disease were significantly more likely to make abrupt changes in direction and drive slower.
The changes were so stark, researchers were able to create a model to predict if people had Alzheimer’s based on their driving alone.
The model predicted cases accurately in 90 percent of the people.
Another sign of Alzheimer’s can become more of a potty mouth — particularly in inappropriate situations.
The filter people normally use to stop themselves wearing in front of children, for example, is no longer as strong, resulting in more profanities.
Researchers from the University of California, Los Angeles, found 18 percent of people with FTD used the word ‘f**k’ when prompted to name words beginning with ‘f’. This compared to none of those who had Alzheimer’s.
The study of 70 patients, published in Cognitive and Behavioral Neurology in 2010, asked patients to name as many words as they could think of beginning with letters ‘f’, ‘a’ and ‘s’ in a minute.
While the study did not provide any raw data, it showed six of the 32 dementia patients said the swear word when asked to list words for ‘f’, and more said the word ‘s**t’ for ‘s’.
Having no filter
Similarly to swearing, as Alzheimer’s patients’ brains change, they’re able to filter what they say and how they tend to degenerate in many cases.
People can become rude, say inappropriate things, start undressing in public or begin talking to strangers more often than they previously would have.
Experts say patients can also lose their sexual inhibitions in some circumstances, for example by touching inappropriately in public.
They believe the change is caused by brain shrinking in the frontal prefrontal cortex in the frontal lobes of the brain — the part that controls our filter.
Alzheimer’s Society said: ‘These situations can be very confusing, distressing, shocking or frustrating for someone with dementia, as well as for those close to them.
‘The person with dementia may not understand why their behavior is considered inappropriate. It’s very unlikely that they are being inappropriate on purpose.’